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Sergio Ruiz-Carmona
I am currently a Research Officer and Bioinformatician at the Baker Institute, under the supervision of professor Mike Inouye. My research interests are broad and involve the relationship between genetic variants and their effect on protein structures.
I carried out my MSc and PhD in Barcelona in the Barril Lab, where I worked with different structure-based drug design methods with the aim to improve drug design for non-standard targets.
Selected Education
PhD in Biomedicine
Universitat de Barcelona
Barcelona, ES
2017 - 2012
- Virtual Screening for novel MoA: Apps. and method developments
- Development and application of structure-based drug discovery methods
- Awards: Extraordinary prize for PhD Thesis and Ramon Margalef award for best publication
Selected Positions
Research Officer and Bioinformatician
Inouye Lab
Baker Heart and Diabetes Institute
Melbourne, AUS
Today - 2019
- I am working in a project that overlaps Structural Biology and Genomics, trying to understand how rare missense variants alter protein structures and can induce disease
Postdoctoral Researcher
Barril Lab, Universitat de Barcelona
Barcelona, ES
2019 - 2017
- After finishing my PhD, I worked in exciting collaborative projects in the field of epigenetics and cancer, where I carried out multidisciplinary research and learned new experimental skills
Associate Professor
Faculty of Pharmacy, Universitat de Barcelona
Barcelona, ES
2019 - 2015
- Classes in Pharmacy, Food Science and Nutrition degrees (total 400h)
EMBO Short-Term Fellow
Andreas Bender Lab, Unversity of Cambridge
Cambridge, GB
2017
- I spent 2 months in one of the main Pharmacogenomics groups in the world, where I used gene-expression profiles of different biological systems to study BRD4 and drug selectivity
Skills and Training
Computational Tools
Drug Discovery (Virtual screening, Molecular dynamics), Machine learning, Data visualization, Statistical analysis, REDCap, Bioinformatics and Data analysis
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Programming
R, Python, Perl, C++, LaTeX, Bash, Java, MySQL, HTML/CSS and Android and Web Development
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Management Skills
2021 EMBO Practical Course: Research to service: Planning and running a bioinformatics core facility; Mental Health and OHS certifications
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Outreach and other activities
Australasian Leadership Computing Grants
Story about NCI Computing Grant
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2021 - 2020
- Together with Mike Inouye, we were awarded a 1 year computing grant by the Australian National Compuational Infrastructure to study COVID-19 proteins and possible drug treatments
New tools for new medicines, The Conversation article
Lay-summary of some of my work and opinion for The Conversation Spain
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2021
COVID-19 daily dashboard, until Nov 2020
Personal project to showcase COVID-19 evolution in Victoria during major lockdown in 2020
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2020
Main Scientific Output
The carbon footprint of bioinformatics
Molecular Biology and Evolution
Read it here
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2022
- Jason G Grealey, […] Sergio Ruiz-Carmona, Michael Inouye
Oxygen Pathway Limitations in Patients with Chronic Thromboembolic Pulmonary Hypertension
Circulation
Read it here
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2021
- Erin J Howden *, Sergio Ruiz-Carmona *, […] Andre La Gerche, Marion Delcroix and Guido Claessen
- Result of a Bioinformatics Core collaboration. Shiny app developed
Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner
iScience
Read it here
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2021
- Aowen Zhuang, A Calkin, […] Sergio Ruiz-Carmona, […] and Brian G Drew
- Result of a Bioinformatics Core collaboration
Dynamic undocking and the quasi-bound state as tools for drug discovery
Nature Chemistry
Read it here
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2017
- Sergio Ruiz-Carmona, Peter Schmidtke, […] Rod Hubbard and Xavier Barril
- Highlighted in its issue cover
rDock: a fast, versatile and open source program for docking ligands to proteins and nucleic acids
PLoS Computational Biology
Read it here
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2014
- Sergio Ruiz-Carmona, Daniel Alvarez-Garcia, […] Xavier Barril, Rod Hubbard and S David Morley